Studies on thyroid and hypophysary thyrotrophic hormone (TSH) in Down syndrome

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Studies on thyroid and hypophysary thyrotrophic hormone (TSH) in Down syndrome.

Serum TSH was studied in 22 patients with Down syndrome, from 4 to 15 years old. In 6 of these patients radioidine uptake by thyroid gland after 2 and 24 hours of administration and clearance rates before and after TSH stimulus (10 mul-IM) were measured. Results show that serum TSH was normal in 17 patients and above normal limits in 5 patients. Thyroid uptake after 2 hours as well clearance ra...

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THYROID FUNCTION TESTS Thyroid Stimulating Hormone (TSH): The thyroid stimulating hormone (TSH) assay measures the concentration of thyroid stimulating hormone in the serum. TSH assays

The thyroid stimulating hormone (TSH) assay measures the concentration of thyroid stimulating hormone in the serum. TSH assays have been classified by "generation" based on the functional sensitivity of the assay, i.e., the lowest concentration at which the assay is able to maintain an inter-assay precision, expressed in terms of percent coefficient of variation (%CV), of 20% or less. Virtually...

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Inappropriate TSH hypersecretion was diagnosed in a 34 years old woman. Earlier she had been treated by ablative therapy for hyperthyroidism. The present diagnosis was based on elevated basal serum TSH levels despite elevated serum free thyroid hormone level. Her TSH responses to TRH (peak value 240 mu/I) was high. Her albumin and prealbumin levels were normal. The serum TBG level, alpha subuni...

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Investigating low thyroid stimulating hormone (TSH) level.

This series of occasional articles provides an update on the best use of key diagnostic tests in the initial investigation of common or important clinical presentations. The series advisers are Steve Atkin, professor, head of department of academic endocrinology, diabetes, and metabolism, Hull York Medical School; and Eric Kilpatrick, honorary professor, department of clinical biochemistry, Hul...

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DOWN\'S SYNDROME: CYTOGENETIC STUDIES IN 150 CASES IN TEHRAN

Cytogenetic studies were performed on 150 cases of Down's syndrome (DS) in Iran. The standard trisomy 21 was found in 132 (88 % ) and translocation-trisomy 21 (+21) in 18 (12%) patients, i.e., t(21,21) in 1(0.63%) and mosaicism in 17(11.33%) cases. The comparison of the frequencies for mosaicism between different populations such as Denmark, Hungary, Egypt, Iraq, India, Australia and Iran ...

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ژورنال

عنوان ژورنال: Arquivos de Neuro-Psiquiatria

سال: 1977

ISSN: 0004-282X

DOI: 10.1590/s0004-282x1977000100001